The Role of Helicobacter Pylori Eradication on the Glycemic Control of Type 2 Diabetes Mellitus Patients: A Prospective Study

Abstract

Aim: To determine the eradication effect of H.pylori infection in improving the HbA1c level in
patients with type 2 diabetes
Background: The potential role of H. Pylori infection on the development and progression of type 2
diabetes mellitus (T2DM) has gained momentum over the recent years, which was supported by the
observations of previous epidemiological studies. Thus, we conducted the present study in order to
determine the association between H. Pylori infection and the glycemic status of T2DM, as well as
the impact of H. Pylori eradication on the glycemic status of T2DM.
Methodology: it was conducted in the department of internal Medicine at Aswan university hospital,
and included 200 patients: group I;100 cases divided into two equal sub-groups (A and B) controlled
and uncontrolled type 2DM patients Respectively and group II; 100 non diabetic patients as control,
The both groups were subjected to eradication of H.P infection according to the international
guidelines then HbA1c was formed before and after 3 months for the uncontrolled group to determine
the eradication effect of h. pylori infection in improving the HbA1c level in patients with type 2
diabetes.
Results: We observed that H. Pylori frequency detected by stool antigen among diabetic patients was
77.0% compared to 55.0% among non-diabetic patients with a statistically significant difference
(p=0.001). Higher frequency of H. pylori antigen was present among uncontrolled diabetic (82.0%)
compared to 72.0% among controlled diabetics without a statistically significant difference
(p=0.235;). HbA1c had a mean of 9.84± 1.6 before treatment and a mean of 7.39±1.02 after
treatment. A statistically significant difference has occurred in HA1c among cases with uncontrolled
diabetes after eradication of helicobacter pylori. (p=0.001).
Conclusion: In conclusion, our results highlighted the high prevalence of H. Pylori infection among
T2DM patients. We found that the eradication of H. Pylori infection led to significant improvements
in the glycemic control among uncontrolled patients. These results add to the evidence on the
potential of H. Pylori treatment in diabetes control and should be confirmed in larger studies.