Evaluation of Mineralized Plasmatic Matrix Prepared from Allogenic Bone Graft in Alveolar Cleft Closure: A prospective Randomized, Triple Blinded, Parallel Clinical Trial

Abstract

Background:Secondary bone grafting has been used for alveolar cleft closure. However, the type of bone graft to be used is still controversy.

Objective: To compare the effectiveness and complications of different bone graft materials used in secondary alveolar cleft grafting.

PatientsandMethods:This prospective randomized study included 66 patients with alveolar clefts. They were classified into two equal groups according to the material used for grafting; group (1) included 33 patients in whom grafting with anterior iliac crest bone was used (Control) and group (2) included 33 patients in whom grafting with MPM prepared from allogenic bone graft (study group).

Results:The outcome of the studied patients 3 months postoperatively; 31 patients (93.93%) and 32 patients (96.97%) had complete cleft closure in the control group (1) and MPM group (2), respectively, while partial cleft closure was observed in only 2 cases (6.06%) and 1 patient (3.03%) in groups (1) and (2), respectively. No cases had operation failure in both groups. They all showed statistically non-significant difference (p >0.05) in comparison between both groups.

Conclusion:The study concluded that the side that contained allogenic MPM showed no differences from the side that contained iliac bone graft either in oronasal fistula closure or grafted bone volume with no donor site and its subsequent morbidities.