Study of Estrogen Hormone as Antioxidant for Healthy Pregnant in Kirkuk City

Abstract

The antioxidant resistant system of the human body is depend on the balance between free radicals production and presence of antioxidant substances in pregnancy.  Oxidative stress is closely related to the  marker of lipid peroxidation malondialdehyde( MDA), while antioxidant marker is  glutathione (GSH), and sometime estrogen hormone is regarded as indicator of antioxidant. The aim of study to indicated the action of estrogen acts as antioxidant in healthy pregnancy  . Methods: A total of 92 healthy female were included in this study,23 non pregnant women control groups and made up of 69 healthy pregnant women 23 per each trimester, and whose ages ranged between 19 years and 42 years. Result :The level of MDA gradually significant increased early state for the pregnant women (p<0.05) at the third trimester as compared with non-pregnant control groups, however a significant decreased in GSH level at first trimester as compared to no pregnant control groups. There was an observed increase in level of estrogen at third trimester as compared to control groups. So the present result showed that there was significantly increased in level of MDA & serum estrogen in third trimester, while level of (GSH) decreased at the same state. Conclusion : The risk factors for pregnant women which represented by increased MDA and decreased GSH become more clear with increase in body mass index of pregnant women (BMI) in first trimester and the antioxidant mechanism action of estrogen is probably associated with increased activity of  antioxidants mechanisms of body during third stage of pregnancy by diminishes the free radicals .