MEBO Ointment Acts As Antioxidant in Burns Patients

Abstract

Burn injuries are associated with anatomically within physiologically infections and biochemically within immunologically defect in hepatic functions during direct action on locally and systematic role of blood elements and liver enzymes. These defects represented the cellular response due to burn injuries. Aim of study:  to assess the treatment and antioxidant action of  MEBO ointment in medical therapy ,such as burn therapy. Methods: The study was performed by 66 burn patents(male) received treatment with ointment MEBO(100g)twice daily for two weeks and all patients have thickness burn injury, age ranged(15-65years for all subjects) and 50 men healthy control subjects ,So one day post burn samples were collected for hematological &biochemical parameters in kirkuk city at Azaadi hospital ,and this study done from  march to December 2019 .  Results: Leukocytes count (WBC), Neutrophil,  lymphocyte,) and erythrocyte sedimentation rate ( ESR) were increased, while red blood cells count (RBC), hemoglobin (HB) were decreased after burn injury. Creatinine and potassium element are increased significantly, while Sodium element was decreased and significantly increased in the liver enzyme and glutathione after treatment when MDA significantly decreased .Conclusion: This study concluded that blood parameters and liver functions were altered due to burn injuries and these modulations attributable to the lipid peroxidation(MDA), while the liver enzyme signaling of hepatic activity for glutathione synthesis for curbing the free radicals after treatment by MEBO ointment ,this productive mechanism may be new defect liver mechanism for burn injury.