Evaluation the levels of visfatin,omentin,endothelin-1 and homocysteine in women with breast cancer

Abstract

This study was carried out at the Oncology Center in Kirkuk-Iraq, the period from october 2020 to march 2021, This study included (70) disease cases for women with breast cancer, their ages ranged between (25-65) years from Kirkuk Oncology & Hematology Center (Kirkuk- Iraq), and this study also included (20) samples of healthy women as a control groups in same ages. and aimed to assess the changes of levels of visfatin, omentin, endothelin-1 and homocysteine features in affected women who suffers from breast cancer in specific areas which is Kirkuk city. The results illustrated a significant increase in P value (P ≤ 0.001) in the concentration of visfatin ,omentin endothelin-1 and homocysteine for women with breast cancer by comparing it to the control group. These results of visfatin in women with breast cancers was 23.16(17.35-33.76) ng/ml compared to control group 4.40(3.05-5.32)ng/ml . And the result of omentin in patient was 12.55 (10.39-14.91) ng/L compared to healthy control group 3.59 (2.59-5.07) ng/L. The results of endothelin-1 in patient was 30.0(25.26-36.48)ng/L comparison to healthy controlled humans 10.43 (7.22-12.44)ng/L. and the results of homocysteine in patient was 20.99(16.76-31.86)nmol/ml compared to healthy control group 2.77(1.300-6.91) nmol/ml. Conclusion This provides an sign of supporting the important role of stromal-tumor relations with breast cancer.