Free Radical Activity in Thalassaemia Major Patients in a Tertiary Care Teaching Hospital, Bhubaneswar

Abstract

Thalassemia is an entity involving a collection of inherited diseases caused by defective or absent hemoglobin chain synthesis leading to anemia due to ineffective erythropoiesis. Two hundred and fifty one diagnosed thalassaemic subjects from 6months-40 years of age attending thalassaemia care centres in Bhubaneswar were investigated for Plasma MDA /SOD and RBC SOD. The control group shows SOD levels 5.98±1.72U/ml (RBC) 3.79±1.42 U/ml (Plasma) & Plasma MDA 6.86±1.72 nmol/ml. In beta Thal patients RBC-SOD was 13.76±2.22 U/ l and Plasma-SOD 08.100±1.88 U/ l, Plasma MDA 15.12±2.28 nmol/ml was observed.Plasma SOD & MDA in thalassaemia major patients is raised due to generation of production of Reactive Oxygen Species (ROS) as a consequence to formation of hemichromesheamolysis of Red Blood Cells and Iron overload.