Formulation And Evaluation Of Ganciclovir Solid Dispersions

Abstract

The present research work was aimed for an innovative study to explore the best among the better carriers for preparing solid dispersions (SDs) using novel microwave fusion technique by taking Ganciclovir (GCR) as model drugs. The successful carriers of Poly Ethylene Glycols (PEG-3350, PEG- 4000, PEG-6000, PEG-8000 and PEG-20000); Poly Vinyl Pyrrolidone (PVP K-12, PVP K-17, PVP K-25, PVP K-30 and PVP K-90); Poloxamers (Poloxamer 108, Poloxamer 188, Poloxamer 237, Poloxamer 338 and Poloxamer 407) and Urea were prepared as SDs by microwave induced fusion technique for increasing the solubility of GCR and LPR. Drug and carrier compatibility studies were performed. The prepared SDs were assessed for flow ability and compressed into tablets. The resulted tablets were characterized for physical parameters viz., thickness, weight uniformity, hardness, friability, uniformity in drug content, solubility and in vitro dissolution. The optimized formulation from GCR (combination of carrier blends) was further made a combination. A HPLC technique was established for the instantaneous assessment of the optimized combination of GCR.