In-vivo & In-vitro Antioxidant Potential of Combination Drug Amlodipine and Atenolol used in the Management of Hypertension

Abstract

We know that the drugs are used in the combination have great importance as combination therapy. It has been well recognized in the treatment of hypertension. Clinically when we used combination therapy in the management of hypertension it will be produce better efficacy than the single drug. In the management of hypertension, β-adrenergic blockers and calcium channel blockers are widely used. From both classes we select Amlodipine and Atenolol drugs for our antioxidants activity. Here, we investigated the protective capacity of both drugs in combination against high glucose (HG) elicited oxidative. The activity of lactate dehydrogenase (LDH), NADPH oxidase (NOX), superoxide dismutase (SOD), catalase (CAT) as well as the levels of malondialdehyde (MDA), glutathione (GSH), intracellular reactive oxygen species (ROS), and all other in-vitro & in-vivo antioxidant experimental models. In these findings we found that amlodipine and Atenoolol in combination has protective effects on Management of Hypertension Keywords: Antioxidant; DPPH; SOD; Amlodipine; Atenolol.