Transdermal CO2 Increases Perfusion Index in Patients with Placenta Accreta Following Temporary Abdominal Aortic Cross-Clamping

Abstract

Clinal management for patients with placental accreta could involve surgeries with the risk of massive bleeding. To overcome, the use of abdominal aortic cross-clamping is suggested. Nonetheless, the procedure could cause ischemic complications with worsening tissue perfusion. In this present study, the transdermal CO₂ was used as a mean to recover the tissue perfusion of placental accreta patients following the abdominal aortic cross-clamping. The transdermal CO₂ was administered via non-invasive vaporization technique accommodated by deoxyhemoglobin vasodilator (D’Oxyva). The perfusion indices (PIs) from each time of post-abdominal aortic cross-clamping (0-30 minutes) were measured using an oximeter as an indicator for tissue perfusion. Our data suggested that the mean PIs in treatment group were significantly higher than in the control group at all observation times (p<0.001).The mean PIs during and after abdominal aortic cross-clamping in treatment group was 5.6-foldhigher than control group (p<0.001).Overall, the results suggest that transdermal CO₂ could improve the tissue perfusion after the abdominal aortic cross-clamping procedure in placental accreta patients.