Phenotypic Characterization And Anti-Fungal Susceptibility Of Candida Species Isolated From Various Clinical Samples Of Immunocompromised Patients In A Teritiary Care Hospitals.

Abstract

Candidiasis is a primary or secondary mycotic infection caused by members of the genus Candida.The clinical manifestations may be acute,sub acute or chronic.Involvment may be localized to the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs or the gastrointestinal tract which become systemic in septicemia, endocarditis and meningitis. Candidiasis are the most common infection among immunocompromisedpatients  despite many advances in antifungal therapy. Candidiasis remains significant cause for the patient morbidity and mortality. Species identification is done by KOH direct mount, gramstain, germ tube test , culturing on SDA, chlamydospore formation. Antifungal   susceptibility done by disc diffusion method. Out of 200 various clinicalsamples, 51 isolates were Candida spp. The most common isolates were Candida albicans (70.59%),Candida tropicalis (21.57%), Candida guillerimondi (3.92%),Candida parapsilosis (1.96%),Candidadubliniasis (1.96%). Among antifungal susceptibility, Nystatin (86%) is  more sensitive  than amphotericin B (51%) and 100% strains are resistance to itraconazole.These  results incriminated Candida albicans as the most common Candida species causing candidiasis in immunocompromised  patients . thissuvilence study has established nystatin and amphotericin B as very effective anti fungal agents for the treatment of candidiasis.