A Review On Matrix Metallo Proteinases And Its Role In Periodontal Diseases

Abstract

Matrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn(++)-endopeptidases that collectively cleave most if not all of the constituents of the extracellular matrix. This review article discusses in detail the types of MMPS, its biological actions and role in periodontal disease. The regulation of MMP activity at the transcriptional level and at the extracellular level (precursor activation, inhibition of activated, mature enzymes) is also discussed.