Association of MET12 Gene Mutation with the Benign Breast Cancer in Iraqi Woman

Abstract

The most prevalent form of benign breast cancer is Fibroadenoma, in fibroepithelial tumorigenes is the gene which play a key function  is asomatic mutation in the MED12 gene (mediator complex subunit 12). The present research examined thebenign tumor tissue from Iraqi women's for existence of the MED12 gene  mutations or not. Total samples tested by reaction-Sanger chain polymerase sequencing was 100 (50 fibroadenoma and 50 healty blood as a control).Results showed that the variant represent35% (7/20) of fibroadenoma samples. consist of six unique intronic mutations And 14 unique exonic differences, These results suggest that this gene cannot consider as aindicator for the pathogenesis of fibroadenoma and do not have a role in its incidence.