The Effect of Furfural on the Histological Structure of the Kidneys in the Adult White Rabbit.

Abstract

This study was designed to investigate the effect of furfural on the tissue structure of the kidneys in the white rabbit (Oryctolagus cuniculus). The study included 12 white rabbits, ages ranged between 5-8 months and weights 1-1.99 kg. The animals were divided into four groups each group contained 3 rabbits: The first group included the control group, the second group ingected with furfural at concentration of (50 mg), the third group(100mg)and the fourth groups (150mg). In groups (First, Second, Third and Fourth) animals of the three groups were injected with furfural substance under the skin at a concentration of (50mg, 100mg, 150mg) of furfural for 30 days, treatment with furfural led to the emergence of pathological conditions in the tissues of the kidneys, including necrosis and the occurrence of cell leaching as well as congestion in the blood vessels, enlargement of the vessel wall, and fibrosis around the blood vessels and the emergence of a state of edema.Other degenerative changes include the dissolution of some tubule cells and the detachment of others from the basement membrane and their collection inside the cavities of the renal tubules. The results showed that there was a shrinkage in the glomerulus and the expansion of Bowman's space by increasing the concentration of the treated substance, and there were clearly significant differences compared to the control group at a probability level of 0.05.