The State of the Intestinal Microflora and Assessment of the Health State among People with Impaired Glucose Tolerance

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Sanjar Kholboyev, Khidoyat Rahimova, Nilufar Sulaymanova


Diabetes mellitus is considered one of the most important medical and social problems of our time. One of the most promising areas in the fight against diabetes is primary and secondary prevention. With diabetes, the liver, stomach and intestines are affected. At the same time, it was shown that in patients with diabetes there is a violation of normal intestinal microbiocenosis. In turn, a violation of the intestinal microbiocenosis can cause pathological changes in various organs and reduce immunity.In this regard, early detection and correction of various risk factors for diabetes is of great importance.

The aim of the study: To study the state of the microflora of the large intestine and assess the state of health among persons with impaired glucose tolerance.

Materials and research methods: We examined 16 patients with 2 types of diabetes, 32 patients with IGT and 50 people without DM and IGT. Persons with manifest diseases of the gastrointestinal tract were excluded from the examination. The medical examination included the following methods: questionnaire, biochemical, instrumental and microbiological. Along with the generally accepted methods of examining patients with gastrointestinal pathology (ultrasound of the liver, pancreas, X-ray, gastrofibroscopy, sigmoidoscopy and fecal analysis, etc.), their glycemic levels were also studied.

Research results:According to these criteria, the incidence of normal glucose tolerance, IGT, and diabetes mellitus was 51.02%, 32.65% and 16.33%, respectively. When analyzing the frequency of normal glucose tolerance in the age groups of 30-39 years old, 40-49 years old and 50-60 years old, it was shown that it is 45.45%, 60.00% and 47.83%, respectively. The incidence ofIGTin the corresponding age groups was, respectively, 45.45%, 20.00% and 34.78%, and the frequency of diabetes mellitus in these groups was 9.09%, 20.00% and 17, respectively. 39%. In connection with the above, an analysis of the frequency of intestinal dysbiosis was carried out among persons who differ in their assessment of their health. Among people who do not see a doctor, the incidence of intestinal dysbiosis is 100%. Among those who turn to doctors only when they feel very unwell, the frequency of intestinal dysbiosis is slightly less (82.93%), and less often (66.67%) intestinal dysbiosis occurs among those patients who always turn to doctors when they worsen. well-being. These data indicate the important role of timely referral of patients to doctors. At the same time, these data indicate that even a timely visit to doctors does not always give the desired effect, because patients, as a rule, turn to a doctor with other complaints and other pathologies.

Conclusions:The data of the present study make it possible to supplement the risk groups of intestinal dysbiosis with persons with impaired glucose tolerance. Impaired glucose tolerance is a risk factor for intestinal dysbiosis. Intestinal dysbiosis is associated with a violation of both the sympathoadrenal phase of the glycemic curve and the vagoinsular phase. The results of the study allow to optimize the treatment tactics in patients with dysbiosis with insulin resistance. The results of this study can be used in preventive programs for the prevention of intestinal dysbiosis in persons with impaired glucose tolerance.

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Sanjar Kholboyev, Khidoyat Rahimova, Nilufar Sulaymanova. (2021). The State of the Intestinal Microflora and Assessment of the Health State among People with Impaired Glucose Tolerance. Annals of the Romanian Society for Cell Biology, 163–176. Retrieved from