Evaluate the Clinical and Radiological Outcomes of Platelet-Rich Fibrin in of Periodontal Intrabony Defects: A Systematic Review and Meta‐Analysis

Abstract

Background and aim: In the present study, tried to obtain strong evidence by comparing Platelet-rich fibrin in the treatment of both intrabony defects with other treatment methods used for periodontal reconstruction, so the aim of present systematic review and meta‐analysis was evaluate the clinical and radiological outcomes of Platelet-rich fibrin in of periodontal intrabony defects.

Method: From the electronic databases, PubMed, Embase, Cochrane Library have been used to perform a systematic literature over the last five years between February 2015 and May 2021. For Data extraction, two reviewers blind and independently extracted data from abstract and full text of studies that included.Moreover mean difference with 95% confidence interval (CI), fixed effect model and invariance method were calculated. Random effects were used to deal with potential heterogeneity and I² showed heterogeneity. I² values above 50% signified moderate-to-high heterogeneity. The Meta analysis have been evaluated with the statistical software Stata/MP v.16 (The fastest version of Stata).

Result:A total of 314 potentially relevant titles and abstracts were found during the electronic search, Finally21 studies required for this systematic review. Overall Mean difference of PD and Clinical attachment level between platelet-rich fibrin and control group was 0.65mm (MD, 0.65 95% CI 0.59, 0.71. P= 0.0.00) and 0.23mm (MD, 0.23 95% CI 0.18, 0.28. P= 0.00), Respectively.

Conclusion: The present study shows that open flap debridement / platelet-rich plasma can reduce Probing depth, clinical attachment level and Radiographic bone fill, also lead to clinical improvements.