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Vitamin D shows an important role in immune function. However,there is still little analysis regarding the role of vitamin D inpreventing infection and death fromCOVID-19.This researchaimed todetermine vitamin D levels inpatients with confirmed COVID-19. A cross-sectional study was conducted. Researcher collected blood fromthemedian cubital vein of COVID-19 patients and examined the vitamin D levels in patients using the ELISA method.This research showed a comparison of serum vitaminD based on clinical manifestations of COVID-19 patients in all subjects. In20 patients with symptomatic COVID-19 clinical manifestations there were 17 patients (85 %) with vitamin Ddeficiency, 3 patients (15 %) with vitamin D insufficiency; To the contrary, there were noasymptomatic COVID-19 patientswith vitamin D deficiency, 18 patients with vitamin D insufficiency, and 4 patients with normal vitamin D levels.There was a significant relationship between the clinicalmanifestations of patients with COVID-19 and the patient's serum vitamin D levels where asymptomatic patientshad higher levels than that of symptomatic patients (p-value with the Chi-square test was 0.000 with p <0.001).In addition, there was a significant difference between vitamin D levels in asymptomatic and symptomatic patients whereserum vitamin D levels were obtained to be higher in the asymptomatic patient group than in thesymptomaticgroup.