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A total of 161 patients who had been ill with Covid-19 were examined, who were at the Research Institute of Virology in inpatient treatment from March to May 2020. The diagnosis was confirmed by PCR. The duration of the retention of the specific humoral immune response of IgG antibodies against the SARS-CoV-2 virus was studied by the IHLA method. The authors found that after recovering from Covid-19, the IgG humoral immunity lasted up to 8-9-10 months. The duration of the preservation of specific immunity, IgG antibodies against the SARS-CoV-2 virus did not depend on the severity of the disease. And it may be due to the climatogeographic features of the region, the polymorphism of genes responsible for the immunopathogenetic mechanisms of the immune response of the population of the Republic of Uzbekistan, and the hyperendemicity of the region for the widespread prevalence of bacterial-viral, fungal and parasitic diseases responsible for the formation of cellular and humoral mechanisms of the immune response. Research in this area should be continued.