Macular Thickness analysis of different quadrants among various Diabetic Retinopathy Groups of Type-II Diabetic Individuals using Optical Coherence Tomography

Abstract

A case control method was utilized in this study to learn more about the macular thickness variations among a pool of Normal controls and Type - II Diabetic individuals using spectral-domain OCT and classifying, evaluating them further into diabetic retinopathy sub-groups.

A scanning was performed for square area of 6 mm surrounding optic disc ,in a series of 6 quick scans for selected participants those who were enrolled using technique (n = k{Z_a+Z_b}²× {s₁²+s₂²}/d²) at confidence interval being capped at 95%. An automated algorithm of OCT scanned the central retinal region having a variable thickness in three concentric circles (primary central circle 1 mm of the optic disc as well as macula). All four major quadrants (superior, nasal, inferior, temporal) along with cube volume and cube average thickness were scanned from centre to inner (3 mm) and an outer circle (6 mm). To evaluate the significance of outcomes (p <0.05), 210 participants (420 eyes) each group having 30 individuals (60 eyes) (mean age 54.54 ± 9.67 years) were analyzed by employing One - way ANOVA using post hoc test and independent sampling T-test method. The outcome was linearly dispersed regarding gender-wise sampling, duration/severity of this disorder, visual acuity and IOP.  Though, the majority of the intra group contrast have proven insignificant, considerably increased macular thickness (p <0.05) was detected among the CSME group in comparison to severe group. Even though the proposed theory managed enough to afford substantial statistics, a thorough strategy is critical to figure out a multitude of facets changing macular depth using more assets along with instrumentation.