Leptospira: A Review on Pathogenesis and Host Immune Response

Abstract

Leptospirosis, the world's most common zoonotic disease and is a growing public health concern, especially in developing countries. The genus Leptospira contains many disease-causing organisms which can cause various clinical symptoms from mild flu disease to severe illness with complications of the multi-organ system which may lead to even death. The mechanisms of Leptospira pathogenesis is largely unknown. This article will focus on leptospira pathogenesis and various virulent factors which are involved in leptospira pathogenesis and how it evade the host immune response and it also shed light on host immune response after infection.