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Background: Menstrual cycle has need to a suitable interaction between ovary and hypothalamus PCOS (Polycystic Ovary Syndrome), is a common disordering in women hormone at a certain age. Objective: to study the cytotoxicity of T-lymphocte antigen CTLA4 and its relation with PCOS patients through investigations on 85 women. Materials and Methods: The tag of SNPs in CTLA4 was selected as a potential function according to the protocols issued by 1000 Genomes Project to develop a resource on human genetic variation. The study was carried out in Kamal Al-Samarrai hospital, the investigation was carried out on 85 women (45 individuals with PCOS patients), the second group was the control (40 healthy individual). Biochemical and clinical hyper-androgenism, which are, acne, hirsutism, the value of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and a history of menstrual disorders. The tagging variants rs11571316, rs62182595, rs11571315, and rs733618 in CTLA4 gene were identified and detected as well. Results: the differences between control (healthy women) and patients with PCOS were compared in whichever genotypes or the distribution of allelic (p>0.001) for rs11571316, rs62182595, rs11571315, and rs733618. Results also show the acne, hirsutism, FSHL, LH, and the insertion of testosterone in both PCOS and control groups. Conclusions: there is a genetic relationship between SNP of CTAL4 and PCOS, and it confirm the involvement of CTAL4 and genotype frequencies such as rs11571316, rs62182595, rs11571315, and rs733618 this correlation may regulate the activation of the T-lymphocyte, as well as their effect on the susceptibility to schistosomiasis.