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This article presents the experience of using photodynamic sanitation of the abdominal cavity using methylene blue as a photosensitizer at a concentration of 0.05% in generalized peritonitis. For patients in the control group of patients, 0.02% aqueous solution of chlorhexidine was used to sanitize the abdominal cavity. It was found that when using the "FDU-1" apparatus with a wavelength of 630 ± 20nm as a radiation source, the following parameters are required: exposure time 3-5 minutes per irradiation area, output radiation power in continuous mode 100mW / cm2, energy density from 25 to 35 J / cm2. On the basis of the data obtained, it was proved that, in terms of bactericidal properties, 0.02% chlorhexidine solution is inferior to the method of photodynamic exposure with methylene blue. The introduction of the developed method of sanitation of the abdominal cavity made it possible to reduce postoperative complications from 23.5% to 13% and to reduce the average length of hospital stay from 9.3 ± 0.32 to 6.5 ± 0.21 bed-days.