Improvement of the Method of Plasmosorption in Liver Insufficiency on the Background of Mechanical Jaundice and Estimation of its Efficiency in Experiment

Abstract

To enhance the sorption effect during extracorporeal detoxification in order to correct hepatic failure against the background of obstructive jaundice, a method of plasma sorption based on the use of a new domestic carbon nanoporoushemosorbent in combination with laser irradiation of blood plasma is proposed. High detoxification activity was noted during 2 sessions of plasma sorbent both with a carbon sorbent (a decrease in total bilirubin from 213.8 ± 8.0 to 100.5 ± 6.1 μmol / l), and when using domestic carbon hemosorbent (from 217.3 ± 6.6 to 90.3 ± 5.4 μmol / L), which significantly (p <0.05) differed from the control without plasmasorption, a similar picture was obtained for the parameters of urea, creatinine and ammonia, the values ​​of which were normalized much faster (p <0.05) after the first session of extracorporeal detoxification.