Morphological Features of the Drugs used in Treatment of Anal Incontinention

Abstract

The morphological characteristics of injectable formulations of foreign production "NOLTREX" and local production of "Polyacrylamide gel", "Bioplant" and "Polyacrylamide gel + Bioplant", after injection into the subcutaneous abdomen in laboratory mice, were studied. Morphological studies were studied: fixation of the drug in the subcutaneous part, cell infiltration, vascular invasion and the formation of granulation tissue around the implant. The timing of morphological studies corresponded to 10, 20 and 30 days for 2 mice from each observation group. Intensive cell infiltration in the comparative group, after the introduction of "Noltrex", as well as in the experimental group, after the introduction of the drug "Polyacrylamide gel". With the coordinated administration of the "Polyacrylamide gel + Bioplant" preparations, the granulation capsule around the bolus is less pronounced and formation is noted.