Main Article Content
The end of a woman's reproductive life is marked by the beginning of menopause, which is defined as the last menstruation in a woman caused by the depletion of the ovarian reserve. Premature ovarian failure (POF) is an ovarian defect characterized by premature stop of folliculogenesis before the age of 40. Gonadal inhibin is the main peptide hormone that regulates the synthesis and secretion of FSH during folliculogenesis and spermatogenesis, and the main role of the inhibin is to selectively suppress the production of FSH by the pituitary gland. The aim of this study was to study the effect of the level of inhibin B as a marker of ovarian reserve in women with premature ovarian depletion. In our study, low levels of inhibin B were found among group A and there was a negative correlation between FSH and the level of inhibin B. The hormonal characteristics of patients with POF also suggest that inhibin is the cause of the disease mechanism. Impaired inhibin B secretion has been reported in women with POF.
Thus, the level of inhibin B is not affected by the intake of exogenous estrogen compared to FSH, and it can be used as a non-invasive method for determining ovarian reserve in women with premature ovarian depletion, in order to predict the restoration of fertility.