The Effect of Follicular Fluid Stem Cell Factor on Clinical Pregnancy in PCOS Patients

Abstract

Background: Polycystic ovarian syndrome is characterized by insufficient follicular maturation, either due to gonadotrophic imbalance or the effects of local substances; as well as a decrease in aromatase activity in granulosa cells, which may be a consequence of the low concentration of follicular stimulating hormone. Objective: To assess the effect of follicular fluid Stem Cell Factor (ff SCF) on clinical pregnancy in PCOS. Patients and method: A prospective cross-sectional study conducted at infertility treatment center at Al-Sader Teaching Hospital / Al- Najaf / Iraq, during the period from October 2019 to the end of May 2020. Results: in PCOS group 14/44 (31.8 %) of the patients were presented with clinical pregnancy, while clinical pregnancy in non PCOS group presented in 16/40 (40 %) of the patients. the mean level of follicular fluid was decreased significantly in pregnant PCOS group (235.8±247.4 pg/ml) than that in pregnant non-PCOS group (618.0±170.7 pg/ml) regarding clinical pregnancy, while the follicular fluid was increased significantly in PCOS group (569.2±243.3pg/ml) than that in non-PCOS group (382.9±164.17pg/ml) in patients with no clinical pregnancy.Conclusion: Reduced concentration of ff SCF in PCOS patients compared to non PCOS patients, as the level of ff SCF reduced lead to increase rate of clinical pregnancy.