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Background: Diabetes mellitus (DM) is the most common endocrine disease and one of the chronic condition affecting children . Type 1 DM (T1DM) is a chronic condition characterized by persistent hyperglycemia due to relative or absolute insulin deficiency. T1DM classified to two types:- Immune mediated. Idiopathic. Latent TB infection (LTBI) is a subclinical infection caused by Myobactaeria tuberculosis complex without clinical, bacteriological or radiological evidence of manifest TB disease.Aim of the work: Early detection of latent T.B in type 1 diabetic children at Zagazig university pediatric hospital. To estimate association between type 1 DM and LTBI.Methods:This comparative cross sectional study was conducted over in the period fromoctober 2019 to October 2020. It Included 81 cases had type 1 DM and 81 healthy children as control group. This study was conducted at Zagazig University Pediatric Hospital.
All patients were subjected to the following: Tuberculin test, HbA1C, CBC and BCG scar.Results:In the current study, mean of age among cases group was 10.90 ± 4.47 This study showed that, the percentage of Tuberculin test was higher among cases group than controls group (32.1%, 7.4%) p value= 0.000 .OR estimate for DM on risk of TB was 5.9 (95% CI 2.27 to 15.33). This study showed that, there was no statistically significant difference between positive and negative regarding duration of DM. This study showed that, there was statistically significant increase in HBA1C among Positive than Negative Tuberculin test. This study showed that, there were statistically significant positive correlation between Tuberculin test and HBA1C.
Conclusion: The percentage of tuberculin test was higher among diabetic group than control group. There was no significant difference between diabetic group and control group regarding BCG scar. There was no statistically significant difference between positive and negative tuberculin regarding age and duration of DM. There was statistically significant increase in HBA1C among positive than negative tuberculin test.