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Background:Epilepsy one of the most common and serious brain disorders, is characterized by spontaneous and stereotyped disturbance of sensation, behavior, emotion or motor function resulting from the rapid and local discharges of gray matter Microminerals and trace elements act as crucial components for the development of immunity and provide antioxidant defense in human body The aim of this study were to evaluate the association of trace element (Zn, Cu, and Mn) with epilepsy in children. Methods:Case control study was conducted in Pediatrics Department at Zagazig University Hospital. Laboratory Investigations Including: Serum Trace elements (Zn, Cu, and Mn). Results: Our study showed that, there was a statistically significant decrease in serum zinc (Zn) among cases group than control group. In the present work, there were no statistically significant difference in serum copper (Cu) among cases group compared to control group. Our study showed that, there was a statistically significant decrease in serum manganese (Mn) among cases group than control group. Conclusion: Results of this research work demonstrated that depleted serum trace elements (Zn, Mn) might be associated with epilepsy. In this context, micromineral supplement may be recommended to reduce the risk of being epileptic.