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The antibiotic resistance risk is expandingacross the world and treating bacterial infections has become verychallenging. The present study aims to identify the antibiotic sensitivity pattern of Staphylococcus aureuswhich is isolated from foot ulcersoccurring due to diabetics, and to discover whether they have antibiotic resistance whichis chromosomalor plasmid trait. For 89 different isolates antibiotic sensitivity test was conducted. MRSA isolates were discovered to be resistant to antibiotics such as vancomycin (0%), cloxacillin (17.9%), gentamycin (20.68%) amikacin (10.2%), chloramphenicol (23.1%) and β-lactam antibiotics like cefoxitin (100%) and penicillin (100%). Then followed by antibiotic sensitivity tests plasmid curing was done, and the outcomes were compared with those obtained before plasmid curing. The outcomesdemonstrated that the S.aureusresistance towards Amoxicillin, Amoxyclav, and Cefotaxime was plasmid mediatedone whereas itsresistance shownto Ampicillin and Cirofloxacin was chromosome mediated one.