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The present study was included to determine the inhibitory activity of Tamarix aucheriana extracts on the drug-resistant Klebsiella pneumoniae. Plant samples were collected from Nasiriyah region, southern Iraq. It was dried and ground, then extracted from the sample (the aerial parts of the stem and leaves) aqueous and alcoholic extracts, and qualitative chemical tests were conducted for the extracts to know the active components in them. The efficacy of these extracts was tested at concentrations (100%-75%-50%-25%-15%-5%) on Klebsiella pneumoniae isolated from respiratory patients at Al-Hussein Teaching Hospital in Dhi Qar. The results showed a significant effectiveness of the alcoholic extract and less than that of the aqueous extract The extracts with concentrations (100% and 75%) recorded a higher inhibition rate than (50% and 25%) and the minimum inhibitory concentration (MIC) was 5%.