Study on Effects of Liposomal Quercetin on Biochemical Parameters of the Nigrostriatal System of Rats with Experimentally Induced Neurodegenerative Disease

Abstract

The work was initiated to study effects of liposomal quercetin on lipid composition, lipid peroxidation and anti-oxidant system enzymes in the nigrostriatal system of rats with experimentally induced neurodegenerative disease. Despite considerable progress in studying roles of the amyloid-beta protein and the tau protein, microglia and inflammatory processes, as well as of sphingomyelin cycle and free radical processes in the onset and progression of neurodegenerative diseases, many issues relating to the significance of all these components remain open. The work is an attempt to study effects of changes in lipid composition of the nigrostriatal system and those of liposomal quercetin on the behavioral performance of animals with experimentally induced neurodegenerative disease. The neurodegenerative disease was induced by a 13-day intranasal administration of rotenone with addition of E.coli, a lipopolysaccharide (LPS), on the 14^th day. Findings from the study demonstrated changes in the lipid composition of the nigrostriatal system of animals with the experimentally induced neurodegenerative disease next to activation of lipid peroxidation and reduction in activity of the anti-oxidant system enzymes. The changes in the biochemical parameters of the system were considered as those causing deviations in behavioral performance of the animals. Liposomal quercetin administered in 30 minutes after administration of rotenone was found to reduce the neurotoxic effects of rotenone and LPS on the biochemical parameters of the nigrostriatal system and behavioral performance of the animals. Findings from the study demonstrated anti-oxidant and anti-inflammatory effects of liposomal quercetin blunting neurotoxic effects of rotenone and LPS; prospects to use it in generation of drugs for therapy of neurodegenerative diseases are under consideration.