Histological Study of Nerium Oleander on the Kidney, Small Intestine and Brain in the Male White Mice

Abstract

The present study designed to evaluated the important histological and some biochemical parameters changes after treated with main compassions of Siqua. The Nerium oleander is one of the main structure of siqua, the study focused on the tissue structures of kidney, small intestine and brain after treated with the watery extract of Nerium oleander. Its caused acute defects in tissue structures of kidney, small intestine and brain of treated white mail mice.After the end of experimental period, the blood samples collecting to evaluation the level of AST, ALT, urea and creatinine in treated animals, then the animals sacrificed for histological study. The current result showed prominent tissue destruction in the cortical region of the kidney in treated animals, the renal corpuscle have significant increase in diameter when compared with control group, wide spaces filled with blood between the proximal and distal convoluted tubules, necrosis lesions in the cortical region and renal tubules wall. The biochemical changes noted significant increase in the enzymes level (AST, ALT, urea and creatinine) of treated group compared with control group.