Main Article Content
The present study aimed to evaluate the histological and physiological changes induced by administration of saccharin on the thyroid gland of mice. Thirty adult male mice used in this study were divided into two groups. The first group used as a control; the second group used as the treated group which treated with 1 ml daily of saccharin solution orally administered for 30 days. After ending the treatment period, blood samples were collectedto assessment of T3 and T4 levels, then the animals were sacrificed for histological study. The results showed the thyroid gland of male after oral administration with saccharin have significant histological differences in most tissue field of thyroid gland, when compared with control group. The physiological results showed a significant difference of hormonal secretions (T3 and T4). Therefore, it can be concluded that treatment of mice with saccharin caused histological and physiological changes in the thyroid gland. So, we should be reducing the use of saccharin as sweeteners and increase public awareness regarding artificial sweetener consumption.