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It is a serious bacterial infection, caused by a bacterium known as Clostridium tetani (Clostridium tetani). The infection with tetanus, occurs through the entry of the Clostridium tetanus bacteria into the body through the contaminated wounds. These bacteria secrete their toxins that affect the brain and nervous system, causing stiffness or stiffness in the body. body muscles. The study aims to assess health care providers' knowledge towards tetanus immunization; and determine the relationship between knowledge and related factors. Methodology: A non-probability (systematic sample) of 100 subject were selected throughout the use of non probability sampling approach and analyzed through the application of descriptive and inferential statistical data analysis approach that includes, frequencies, percentages; and Chi-squared test". Results: "Recent results indicate that most of participants were young male graduated diploma work less than 5 years without training. According to analysis mean of score, findings that majority of 63% were poor knowledge, the education level, years of employment and training sessions have been significant relation with those knowledge at p-value <0.05. Conclusion: More years of experience in training the staff on immunization by local officials help raising professionals’ health workers knowledge and practice. Provide the health resources and exploiting young energies of nurses which indeed helps to develop their knowledge and practice.