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Humans have attempted a variety of wound-healing treatments, including chemical, biochemical, and irradiation therapies, among others. The aim of this study was to compare the effects of saliva extract and low-level laser (LLLT) on cutaneous wound healing. Four groups of twenty straw dogs were formed. Saliva extract was prepared after G1 was obtained, G2 was treated with LLLT, G3 with saline, and G4 was not treated at all. Many of the groups had surgical cutaneous incisions on their backs that were treated. The wound contraction measurements of G1 were less, the tensile strength of G1 was higher, and histological examination showed that by the third week, the normal contour of the skin surface had been restored, with the development of new hair follicles, reduced cellularity of the wound site, and the growth of new blood vessels. The results showed the superiority was for saliva extract than LLLT.