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Man has primarily used dogs as a labor force with respect to the rationales for dog domestication. Even the first dogs seem to have offered general economic services, such as hunting, protecting or traveling. The aims of this study were to study the efficacy of ACS in canine traumatic arthritis treatment and to investigate the possibility of replacement of autologous normal SF instead of pathogenic SF. This study was conducted on twenty local straw dogs divided randomly into four groups , each group 5 dogs. Treatment group-1(G1) were treated with autologous conditioned serum(ACS), treatment group-2 (G2) were treated with autologous normal synovial fluid( SF), and positive control group-3(G3) were treated with normal saline and negative control group-4(G4) had no any treatment. These dogs weighing 15± 5 kg., their ages were 9±3 months. Each group kept in separated box and fed fresh meat with ad libitum clean water. Left stifle joint was chosen as the site of induced traumatic arthritis. Under aseptic conditions arthrocentesis was done and 1ml. of SF of all dogs was evacuated for SF analysis. The left stifle joints of all dogs were opened under routine surgery and the cranial cruciate ligament of the left stifle joint was crushed with forceps. The results showed that the replacement of autologous normal synovial fluid was superior than ACS.