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In preparation for treating a case of a facial herpes simplex patient during the times of coronavirus pandemic, the authors appraised the infection control protocols given by various national and international regulations. However, specific information was mislaid which prompted the evolution of the objective of this case report, which is to review infection control in general Prosthodontic practice. An adult male aged 24 years reported for crown placement for an endodontically treated mandibular right first molar. Clinical examination revealed presence of a combination of a soft and hard scab lesion starting about 5 mm below the vermillion border of the lower lip near the right tubercle. The lesion extended about one and a half centimeters vertically with a 1 cm horizontal spread. Histological picture was confirmatory of a healed facial herpetic lesion and regular treatment was done following a strict infection control protocol. The report discusses management and prevention of facial herpes in Prosthodontic practice.