Bisphenol A (BPA) as an Endocrine Disrupting Chemical (EDC) -A Review

Abstract

BPA stands for Bisphenol A [22 – Bis (4 - Hydroxyphenol) propane] is an organic synthetic compound, most commonly exposed chemical in everyday life. BPA is used in hard plastic bottles and as a protective lining in canned food and beverage cans. Bisphenol A (BPA) is an old synthetic chemical widely known for endocrine malfunctions and replacement of the estrogenic activity of diethylstilbestrol.¹ Various environmental pollutants are manmade chemicals like polymerised form of biphenyls and bisphenol-A have several developmental effects on endocrine and reproductive functions of living beings. Bisphenol-A causes wider effects even at low doses in both terrestrial and aquatic animals and effects major disturbances at endocrine, immune and metabolic level.² Since BPA is known to have ‘selective estrogen receptor modulator’ properties and epigenetic regulations. It affects multiple reproductive organs such as testis, ovariesetc.as it causes reproductive biohazard and endocrine disruption.³ This review summarizes the highlights of BPA as an Endocrine disrupting chemical (EDC) and how it effects multiple organs in the body.