Study of Indicators of Endothelium Dysfunction in Young Patients with Myocardial Infarction

Abstract

The aim of this study was to study indicators of endothelial dysfunction - platelet aggregation activity, a humoral marker of von Willebrand factor, indicators of oxidative stress in young patients with myocardial infarction. 74 patients with acute myocardial infarction (AMI) were examined. The patients were divided into 2 groups: 38 AMI patients of young age made up group 1 and 36 patients with AMI over the age of 60 years made up group 2. The analysis of the obtained data showed that among the risk factors in young AMI patients, smoking was reliably frequent, there was an increase in the aggregation ability of platelets and the level of VWF in the blood plasma, an increase in the processes of oxidative stress, characterized by an increase in the MDA content and a decrease in the activity of the antioxidant system. At the same time, high MDA indices were associated with the anterior localization of AMI compared with the group of AMI patients over the age of 60 years.