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Background: The Prevalence of Mild depression and cognitive Dysfunction in patient with cardiacdiseases due to high Medical and Surgical interventional demand and acclimatization difficulty faced by patient during their stay in ICCU is the current challenge in the field of survival. Aim: The Aim of this study is to assess the effectiveness on Anapana meditation technique on laboratory parameter and personal wellbeing of patients suffering from mild depression and cognitive dysfunctions of ICCU After discharge to home and compare the family responseswith demographic variables.Materials & Method:The bibliographic search was carried out by using web of science specially CINHAL,Indian and international psychiatric and cardiac journals, majorreferences from Vipassana research academy Igatpuri about scientific effect of Anapana on human body (especially on cardiac system).A quasi experimental study among 100 participants were enrolled for Anapana technique, where by Anapana tool for before and after score was derived from Laboratory parameters after 30 day continue practice of Anapana at home. Interview technique was used to collect data regarding personal Responses of individual after practicing Anapana. Whereas the demographic variable were also assessed pre-post Anapana meditation technique.Statistical Analysis:Data was stored in MS-Excel, statistical analysis was done in In-Stat Software, For comparison of pre and post data we had applied chi square test p<0.05 was considered as statically significance. Responses demographic variables were compared and analysed by using chi-square testResults:The pre and post comparisons among all laboratory parameters of Anapana technique was carried out, only ECG, Cardiac Enzymes and on Blood sugar level shown the positive impact of Anapana mediattion technique and was found significant hence we could state that this technique really helps tocognitive dysfunction and mild depressive patients.Total five common responses were marked by investigatorResponse no- 1 – Practicing Anapana daily Benefits in improving my mental health by reducing Anxiety ,anger ,stress , tension Intolerance and my irritation. Response no -2 - Practicing Anapana daily Improves my efficiency in my work and productivity. Response no -3 - Practicing Anapana daily beneficial in improving my family life as well as inter personal relationship. Response no -4 - Practicing Anapana daily improves self-awareness. Response no -5 - Practicing Anapana daily benefits in maintaining mental equilibrium and optimise in adverse situation. The demographic variables such as age, domicile, education, religion had positive correlation in reducing depression and cognitive dysfunction among selected cardiac patients.Conclusion: Anapana meditation technique plays important role in cardiac patient of milddepression and cognitive dysfunction, and society gets benefited to save life and money at early stage of risk.