A Study on Association of Vitamin D, Calcium and Oxidative Stress as Factors Involved in the Pathogenesis of Uterine Fibroids

Abstract

Background: Uterineleiomyoma commonly called as uterine fibroids are the commonest smooth muscle tumors that originate from the uterine muscul artissue. Several factors are involved in the pathogenesis like the reproductive hormones-estrogen and progesterone, age, family history, parity, race etc. The prevalencerate is 20-50% in women in the reproductive age group.

Aims and objectives: To analyze the biochemical parameters, vitamin D, serum calcium and oxidative stress marker, Malondialdehyde (MDA) in fibroid cases and to compare the same with healthy study subjects.

Materials and methods: 60 uterine fibroid cases and 40 age matched controls were studied for their biochemical parameters including lipidpro file, liver function tests, vitamin D, serum calcium, phosphorus, complete blood count and Plasma MDA.

Results: Patients with uterine fibroids had earlier age of menarche and first child birth when compared to normal subjects. They were anaemic with low hemoglobin Hb (gm%) 8.8±2.12 against controls 11.3±3.1.Their HDL (mg/dl) was low with mean value 41.4±5.8 compared to control values (52.8±6.7). In liver function tests, alkaline phosphatase (IU/L) was significantly elevated 198.7±31.4 IU/L when compared to the controls with mean value of 112.5±22.6 IU/L. Vitamin D and calcium were significantly lower in the cases than the controls. Uterine fibroid patients have increased oxidative stress level than their counterparts.

Conclusion: Uterine fibroids are more common in the reproductive age groupe specially in women between 30-50 years of age. Most of the patients were anemic, hypocalcaemic with significant low vitamin D level and increased oxidative stress when compared to the controls.