The Relation between Hypothyroidism and Renal Functions in Patients of Renal Diseases

Abstract

Thyroid hormones play important role in ˝advance and developments˝ of the kidney, and the conservation˲ of water and electrolytes hemostasis. Thyroid defunction explanation significant ˱changes in kidney function˲. ˝Hypothyroidism affects renal blood flow (RBF), and tubular function. The most accepted kidney derangement associated with˱ hypothyroidism are, altitude of serum Creatinine levels˲ reduction in GFR and (RBF). The aims of this study were to evaluate, the kidney functions in hypothyroidism. The materials and methods: This study included (70) patients with hypothyroidism,(43) of them with subclinical hypothyroidism and (27) of them with over hypothyroidism participated. The following biochemical parameters have been studied (Triiodothyronine, Thyroxine , Thyroid stimulating hormone, urea, and Creatinine). It was studied and done by mini VIDAS, spectrophotometry and chemistry auto analyzer. From August 2020 to January 2021, sera obtained from patients and control to the estimation of T3,T4,TSH, urea, and creatinine. The consequences of this study display that majority of cases were 30-65 years age of patients and control group. Thyroid dysfunction was found to have 80% more occurrence in CKD patients as compared to normal healthy controls. Most common thyroid dysfunction observed was subclinical hypothyroidism by low T3 syndrome overt hypothyroidism. There was significant reduction of serum T3 level (1.03 ± 0.67ng/ml) T4 level (6.06 ± 2.13 ng/ml) and elevation of TSH level (1.63 ±2.2 μLu/ml) in cases compared with controls. The conclusion was thyroid dysfunction (subclinical hypothyroidism) showed a significant and appearance correlation in patients it’s with CKD and thyroid disorder and patents of CKD various stage of CKD.