The Effect of Remdesivir In Hospitalized Patients with COVID-19: Descriptive Observational Study in Basra Governorate, Iraq

Abstract

Background :"COVID-19,2019" orCoronavirus is an infections malady bring about by acuterespiratory disorder"coronavirus 2SARS-CoV-2". The first case was diagnosed in China, "Wuhan", in Dec. 2019.Then, the virus extends all over the world, causing continuous pandemic.The treatment of the virus basically depends on Repurposed antiviral medications. Remdesivir is the only approved antiviral agent for the treatment of "Covid-19"on Oct. 22, 2020. It is indicated for treatment of Children at the age of twelve and the hospitalized adults. Method : This is a cross sectional observational study hold in single center in Basra governorate at the south of Iraq , the study includes 368 hospitalized patients with "COVID-19" , The variables used in the study includes : The characteristics of patients , As well as the degree of lung involvement from the chest CT , And oxygen saturation . Two groups of patients were included in this study "those who receive Remdisvir, and those who did not kept on Remdisvir during their hospitalization". The outcome of the patient and the duration of hospitalization wereassessed. The statistical analysis was done by using SPSS. Results&Conclusions :The Remdesivir is effective in " 70.9 % " of patients , and the percentage of recovery among those with Remdisvir was higher than those who were not kept on it during their course of illness , and the higher recovery rate is achieved when this drug is administered early during illness. The use of Remdisvir is shorten the duration of hospitalization , especially if used early in disease . The early use of Remdisvir is associated with low incidence of cytokine storm in compare with late or non Remdesivir users. Recommendation :We recommend the early use of Remdisvir during hospitalization , further analytical study is required .