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Background/Aim: Hemophilia A is an inherited bleeding disorder that results from a mutation in FVIII gene, intron 1 inversion is one of the mutations of FVIII gene. We aimed to detect the prevalence of Intron 1 inversion among hemophilia A patients in Basrha/ south of Iraq Subjects and Methods: A screen for the presence of intron 1 inversion at the F8 gene in 95 hemophilia A patient from Basrah at the south of Iraq. All patients have A total genmic DNAwas extracted from EDTA fresh whole blood samples drawn from all participants,then detection of intron 1 inversion by conventional PCR and use of touchdown technique. Results: Not there any one of Hemophilia A patients has Intron one Inversion Conclusions: Absent of intron 1 inversion compare to other studies may be referred to geographic distribution of patients in spite of low prevalence percentage of intron 1 inversion, also more number of patients increase the accuracy of the research.