Investigation of the Correlation between DPD Activity and Renal and Liver Function Parameters in Cancer Patients Treated by 5-Fluorouracil

Abstract

Background:Cancer is a disease that refers to abnormal cell growth, uncontrollably with the ability to spread to other parts of the body."5-Fluorouracil (5-FU), is a commonly used anticancer treatment for different types of cancers with a seriousside effect.Dihydropyrimidine dehydrogenase (DPD) enzyme responsible for the degradation of pyrimidine bases and 5-FU in the body. Aim: This study aimed to determine the relationship between DPD and BMI with Renal and Liver function parameters in 5-fluorouraciltreated cancer patients. Materials and Methods:This study included (88) samples divided into three groups. Group 1 included (28) Control,which is composed of two subgroups, (13) healthy as a (negative control)with age range (27 - 74) years, and (15) patients with cancer (untreated patients with 5-FU) as a (positive control)with age range (24 - 76) years. Group 2 included (30) Colon cancer(treated with 5-FU)with age range (30 - 85) years. Group 3 (30) Stomach cancer (treated with 5-FU)with an age range (16 - 70) years. All the volunteers were selected to investigate the variations in biochemical levels in the sera of cancer patients treated with 5-FU. The sera's concentrations of (DPD, Urea, Creatinine, Albumin, and Total Protein) were measured in blood samples from all volunteers.
Results: The current study findings show no Significant Correlation between the concentration of DPD and all the studied variables for all study groups (p˃0.01). Asignificant positive correlation between the BMI and serum Creatinine [(r = 0.688, p = 0.005)] in Colon cancer. Also, our findingsa significant positive correlation between Blood Urea with Age [(r = 0.708, p = 0.003)] and serum Creatinine [(r= 0.800,p =0.0003)] in patients with Stomach Cancer.Moreover a significant positive correlation between Albumin and Total Protein [(r = 0.760, p = 0.001)] in patients with Colon Cancer .Using Pearson's correlation coefficients.
Conclusion:the DPD activity had No Correlation with Age,BMI, Renal function parametersfor all study groups.the relationship between increasing age, renal function parameters, showed a direct correlation between urea and age. whereas Serum urea and Creatinine levels showed a statistically significant increase between years of age, in patients with Stomach Cancer.
the relationship between increasing age, renal function parameters, showed a direct correlation between urea and age. whereas Serum urea and Creatinine levels showed a statistically significant increase between years of age, in patients with Stomach Cancer.