The Immunological Role of Interleukin-17 in Male Rats Infected with Aspergillosis
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Abstract
Background:Aspergillus sp. Most fungal abundant and the wider spread on the ground and these fungi are adapted with most of the citizen habitat And environmental centers nich Such as air, soil, plant remnants , tree leaves, and old rotting fruits, as well as garbage, sawdust, and stored grains such as wheat, barley, corn, animal feed , and organic fertilizer . They are found in most oxygen-rich environments. (Zulkifli, 2015) And types of genus AspergillusMany majority of medical importance and some of which are economically important but species that are related to diseases with a not fake the clinicalclinically importance sheA. Terreus , A. fumigatus, A. flavus, A.nidulans, A. niger. Methods: The current study included isolation and phenotypic diagnosis of some opportunistic fungi from the lower respiratory tract of patients attending the Consultative Clinic for Respiratory and Chest Diseases in Dhi Qar Governorate( southern Iraq), where 154 sputum samples were collected.sputumFor the period from 1/10/2020 to 2/15/2021.
Aspergillosis was developed in rats after exposure to the fungus Aspergillus fumigatus For one time only, ( 75 ) white male rats were used, and they were divided into (5) groups and according to the following time periods: group (4, 8, 12, 16, 20 days) and an immunosuppressive (cyclosporine) was used according to the above groups.
Aim of Study: The study aimed to investigate the level of Interleukin 17 (Interleukin 17).IL17 )
In the serum of rats infected with Aspergillosis and knowledge of the immune cycle.
Results:Immunological parameters were studied (IL17After infecting rats with Aspergillus disease, using cyclosporin and according to the study groups, where a significant increase in the concentration of Interleukin 17 was found in all groups treated with cyclosporine and mushrooms. A.fumigatus Compared to the control group, while the groups showed treatment with mushrooms A.fumigatus Only a significant increase, but to a lesser degree than (Af + cyclo )
Compared to a control group. The results showed a significant decrease for the total numberWBCs In the groups treated with cyclosporine and mushrooms A.fumigatus Compared to the control group for the time periods (4, 8, 12, and 16 days), while the groups showed treatment with fungiA.fumigatus Only a significant decrease, but to a lesser degree than the totals (Af + cycloCompared to the control group and for the time periods (4, 8, 12 days) compared to the control group. Conclusion:This study concludes with high concentrations of interleukin 17 and other hematological factors in rats infected with Aspergillus.