A Comparative Study of Antibiotic Resistance of Bacteria That Cause Urinary Tract Infection in Diabetic and Non-Diabetic Patients in Najaf City

Abstract

Diabetes mellitus (DM) has been long considered to be associated with an increase prevalence of urinary tract infection (UTI) causing bacteria in comparison with patients without diabetes. One hundred and five urine samples were collected in the study. These samples distributed unequally (23 diabetic males and 14 diabetic females and also 46 non-diabetic males and 22 non-diabetic females).Ten antibiotic were tested in this study Ciprofloxacin 5μg, Cefuroxime 30μg, Amoxicillin 75μg, Chloramphenicol 30μg, Ampicillin 2μg, Cephalothin 30μg, Gentamicin 10μg, Tertracycline 30μg, Vancomycin 30μg, Nalidixic acid 30μg. Results showed that Escherichia coli was the most pathogen present in UTI (27.61%) from Gram negative bacteria followed by Pseudomonas aerugenosa (17.14%), Proteus mirabilis (15.23%) and Klebsiella pneumonia (13.33%). Whilst Enterococcus faecalis was the most pathogen from gram positive bacteria presented in UTI (11.42%) followed by Staphylococcus aureus and Staphylococcus saprophyticus (4.76%) for both and Streptococcus pyogenes and Streptococcusepidermids(2.85%) for both. Ciprofloxacin (82.85%) and Chloramphenicol (76.19%) were the most effective antibiotic against UTI causing bacteria, while the least effective antibiotic was Cefuroxime (22.85%) followed by Cephalothin (25.71%). Conclusion: E. coli was the most dominant pathogen in UTI in both diabetic and non-diabetic patients and the sensitivity of isolated bacteria for used antibiotics was lower in diabetic patients compared with non-diabetic patients.