Evalution of Beta Thalassemia in Young Population with Microcytic Hypochromic Anaemia

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Ruqqaiya Bee, Alok Kumar Srivastav


Thalassemias are the commonest monogenic disorders in the worldwide.Beta Thalassemia Majorhave severe symptoms and life-threatening anaemia. Beta Thalassemia minor may have mild anaemia. Beta Thalassemia Intermedia have moderately severe anaemia are the major disorders that require lifelong management and are to be considered for prevention. In India, Beta-Thalassemia is prevalent across the country, with an average frequency of carriers being 3-4%.This is a cross sectional study conducted between 2017 oct  to 2020 octin Indore in 100 patients as a workup for anaemia and clinically suspected cases of Hemoglobinopathy or beta thalassemia. Blood samples were collected and sent for Haemoglobin Electrophoresis using cellulose alkaline technique.Whole blood sample were analysed for the evaluation of beta thalassaemia in 100 young population who were affected with microcytic hypochromic anaemia. Out of total 12 subjects diagnosed as having three was beta thalassemia major, 02 were males and 01 were females and three was beta thalassemia intermedia, 01 were males and 02 were females. Among the beta thalassemia minor, o4 were males and 02 were females and the remaining 88 were non thalassemia.Most common cause of MHA was 2nd being thalassemia. Differential diagnosis based on complete hemogram and peripheral smear is possible but special tests like serum iron profile and hemoglobin electrophoresis are a must for confirmation of diagnosis.

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Ruqqaiya Bee, Alok Kumar Srivastav. (2021). Evalution of Beta Thalassemia in Young Population with Microcytic Hypochromic Anaemia. Annals of the Romanian Society for Cell Biology, 25(6), 8455–8463. Retrieved from https://www.annalsofrscb.ro/index.php/journal/article/view/7049