Comparison between the Serum Levels of Tissue Matrix Metalloproteinase Inhibitor-1 and Serum Glucose Level in Patient with Traumatic Brain Injury

Abstract

Traumatic brains injury (TBI) it an acquired defect which inhibits brain functions resulting in a complete or partial brain cell dysfunction. One of most commons cause of traumatic brain injuries is car accidents recognized to be one of the more significant severe factors for the increase of mortality and morbidity and the second most common cause is to fall from height .The most frequent ages for brain injury are the Middle Ages. Tissue inhibitor of metalloproteinases-1 (TIMP-1) is the one of the top induced genes in the injured nerve and PNS injury repair or pain effects remain mostly so we analyze TIMP-1 to determined and available features in the damaged PNS.    The Brain has a continuous require for energy that is get by oxidative metabolism of oxygen and glucose so inadequate supply of oxygen or glucose causes cognitive dysfunction and dependent on the duration and severity there will be a progressive deterioration from coma to persistent brain damage and finally death. Samples were taken from 40 infected people and 40 healthy people, and the L-temp-1b enzyme was measured by an ELISA technique, and high blood sugar was measured by a spectrophotometer for the same people, where an elevation was observed serum glucose was also higher in patients than controls (7.96±1.78 mmol/L versus 5.26±1.28 mmol/L) with highly significant difference, Mean serum concentration of TIMP-1 inn patients was 25.06±7.59 ng/ml (range 16.5-44.6 ng/ml) compared with 5.88±2.14 ng/ml (range 2.4-9.7 ng/ml) in controls with highly significant difference. So can use the TIMP-1 as a marker elevated in traumatic brain injury and glucose level is one of parameter that associated with mortality in patient with traumatic brain injury.