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Obesity is a disorder of body weight caused by a collection of excess body fat, it can be classified according to body mass index (BMI). It has spread widely in the world related with many diseases as well as women's health. Polycystic ovary syndrome (PCOS) is a common endocrinologic and reproductive disorder found in about 10% of the female. This study aimed to investigate the risk of obesity on women health by determining levels of some parameters related to oxidative stress for women with and without PCOS. In addition, total oxidant capacity (TOC), total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were evaluated in sera of Iraqi women with and without PCOS; oxidative stress index (OSI) value was also calculated. The participant was grouped according to the BMI into six groups (Each group contains 20 women): Normal weight women with PCOS (PNwt), Overweight women with PCOS (POwt), Obese women with PCOS their BMI ≥ 30 (Pobese). The three patient groups were matched with three apparently healthy women (Normal weight; HNwt, Over weight; HOwt, Obese; Hobese, respectively). TOC, MDA and OSI levels were elevated gradually (p<0.001) from normal weight to obese in sera of in apparently healthy women as well as PCOS women; while The results of TAC were vice versa. However, the differences for the PCOS women were higher than apparently healthy women, based on the above results. Obesity considered as a serious problem and it’s effect is clear on increasing oxidative stress in women, knowing that it’s risk is greater for PCOS women.