Association between IL-6 Gene Polymorphism in Position -174 G/C and Bladder Cancer Risk in Iraqi Population
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Our study included two hundred samples of which 120 patients of bladder cancer in Iraqi population, their ages ranged from 30 to 74 year (ages mean 44.83 ± 1.2) and 80 controls (healthy), their ages ranged from 28 to 67 year (ages mean 33.25±1.7). We confined the frequency of IL-6 Gene polymorphism in position -174 G/C by Tetra ARMS -PCR technique (Tetra-amplification refractory mutation system-polymerase chain reaction technique). Also, we determined the association of IL-6 Gene polymorphism in position-174 G/C with bladder cancer of Iraqi community. Statistical data showed significant difference in genotype frequency of IL-6 Gene polymorphism in positoin-174 G/C with patients and control (healthy). The genotype of CC (homozygotes) show high frequency in bladder cancer patients was ratio 50%, comparison with control was 22.50%, and showed association with etiological fraction risk of bladder cancer. The genotypes of GC (Heterozygotes) and CC (Homozygotes) show low frequency in bladder cancer ratio was 24.17% and 25.83% respectively, while in control show high frequency was 48.75% and 28.75% respectively, also GC and CC genotypes showed relationship with preventive fraction (PF) risk of bladder cancer patients. The G allele show high in frequency of bladder cancer patients comparison with control ratio was 62% and 46.88% respectively, and present with etiological fraction risk (EF) of bladder cancer patients in Iraqi population, while C allele show low frequency in bladder cancer patients comparison with control was 37.92% and 53.13% respectively, and present related with preventive fraction (PF) of bladder cancer patients. Our findings demonstrate that the IL-6 gene in position -174 G/C may represent of bladder cancer risk development of patient’s in Iraqi population.